LYSINOMICIN, A NEW AMINOGLYCOSIDE ANTIBIOTIC II. STRUCTURE AND STEREOCHEMISTRY

PAUL KURATH; WILLIAM ROSENBROOK; DANIEL A. DUNNIGAN; JAMES B. MCALPINE; RICHARD S. EGAN; RUTH S. STANASZEK; MOMIR CIROVIC; SANDRA L. MUELLER; WILLIAM H. WASHBURN

doi:10.7164/antibiotics.37.1130

LYSINOMICIN, A NEW AMINOGLYCOSIDE ANTIBIOTIC

II. STRUCTURE AND STEREOCHEMISTRY

PAUL KURATH, WILLIAM ROSENBROOK, DANIEL A. DUNNIGAN, JAMES B. MCALPINE, RICHARD S. EGAN, RUTH S. STANASZEK, MOMIR CIROVIC, SANDRA L. MUELLER, WILLIAM H. WASHBURN

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JOURNAL FREE ACCESS

1984 Volume 37 Issue 10 Pages 1130-1143

DOI https://doi.org/10.7164/antibiotics.37.1130

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Abstract

The structure of lysinomicin, a new aminocyclitol antibiotic, was established as 3-epi -2'-N-(L-β-lysyl)-4', 5'-didehydro-6'-de-C-methylfortimicin B (1) on the basis of spectral evidence and chemical degradation of the antibiotic. In the course of the degradation of 1, three additional compounds with interesting biological properties were obtained: 3-epi-2'-N-(L-β-lysyl)-6'-de-C-methylfortimicin B (4), 3-epi-4', 5'-didehydro-6'-de-C-methylfortimicin B (6) and 3-epi-6'-de-C-methylfortimicin B (7).

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