VAHOLAMINE, A NEW α-GLUCOSIDASE INHIBITING AMINOCYCLITOL PRODUCED BY STREPTOMYCES HYGROSCOPICUS

YUKIHIKO KAMEDA; NAOKI ASANO; MICHIYO YOSHIKAWA; MASAYOSHI TAKEUCHI; TAKUJI YAMAGUCHI; KATSUHIKO MATSUI; SATOSHI HORII; HIROSHI FUKASE

doi:10.7164/antibiotics.37.1301

VAHOLAMINE, A NEW α-GLUCOSIDASE INHIBITING AMINOCYCLITOL PRODUCED BY STREPTOMYCES HYGROSCOPICUS

YUKIHIKO KAMEDA, NAOKI ASANO, MICHIYO YOSHIKAWA, MASAYOSHI TAKEUCHI, TAKUJI YAMAGUCHI, KATSUHIKO MATSUI, SATOSHI HORII, HIROSHI FUKASE

著者情報

ジャーナルフリー

1984 年 37 巻 11 号 p. 1301-1307

DOI https://doi.org/10.7164/antibiotics.37.1301

詳細

抄録

Valiolamine, a new aminocyclitol has been isolated from the fermentation broth of Streptomyces hygroscopicus subsp. limoneus and its structure has been determined to be (1(OH), 2, 4, 5/1, 3)-5-amino-1-C-(hydroxymethyl)-1, 2, 3, 4-cyclohexalletetrol. Valiolamine has more potent α-glucosidase inhibitory activity against porcine intestinal sucrase, maltase and isomaltase than valienamine, validamine and hydroxyvalidamine which were reported as building blocks of validamycins and microbial oligosaccharideα-glucosidase inhibitors. In addition, valienamine, validamine and hydroxyvalidamine have been isolated from the fermentation broth.

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