IN VITRO BIOLOGICAL ACTIVITIES OF 6-ISOSTERIC PENICILLINS AND 7-ISOSTERIC CEPHALOSPORINS

JOHN C. SHEEHAN; ELSIE CHACKO; THOMAS J. COMMONS; YOUNG S. LO; DAGMAR R. PONZI; ALAN SCHWABACHER; NADINE SOLOMON; ARNOLD L. DEMAIN

doi:10.7164/antibiotics.37.1441

IN VITRO BIOLOGICAL ACTIVITIES OF 6-ISOSTERIC PENICILLINS AND 7-ISOSTERIC CEPHALOSPORINS

JOHN C. SHEEHAN, ELSIE CHACKO, THOMAS J. COMMONS, YOUNG S. LO, DAGMAR R. PONZI, ALAN SCHWABACHER, NADINE SOLOMON, ARNOLD L. DEMAIN

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ジャーナルフリー

1984 年 37 巻 11 号 p. 1441-1448

DOI https://doi.org/10.7164/antibiotics.37.1441

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Antibiotic and penicillinase inhibitor activities of various penicillin and cephalosporin analogs are reported. The compounds include C-6 penicillin and C-7 cephalosporin carbon, oxygen and sulfur analogs obtained by replacing the NH of the amide side chains with CH₂, O and S, respectively. In almost all cases, analogs were considerably less active than the standard compounds (benzylpenicillin and cephalothin), However, some of the analogs act as penicillinae inhibitors.

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