DIHYDROMONACOLIN L AND MONACOLIN X, NEW METABOLITES THOSE INHIBIT CHOLESTEROL BIOSYNTHESIS
1985 年 38 巻 3 号 p. 321-327
詳細
1985 年 38 巻 3 号 p. 321-327
Dihydromonacolin L and monacolin X those are structurally related to monacolin K, a potent inhibitor of cholesterol biosynthesis, were isolated from cultures of a mutant of Monascus ruber. The structures of these two metabolites were determined by a combination of physical techniques. Data for dihydromonacolin L and monacolin X as inhibitors of hydroxymethylglutaryl-CoA reductase and sterol biosynthesis in vitro are also given.
