METHODS FOR THE DETECTION AND QUANTITATION OF ANGIOTENSIN CONVERTING ENZYME INHIBITORS IN FERMENTATION BROTHS
1985 年 38 巻 8 号 p. 993-996
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1985 年 38 巻 8 号 p. 993-996
Two procedures are described for the detection of inhibitors of angiotensin converting enzyme (ACE). The first is a new agar-plate method useful as a screening tool. Two ACE inhibitors produced by culture A58365 were discovered using this plate test. The second method is a modification of a previously reported spectrophotometric procedure. Both procedures utilize p-nitrobenzyl-oxycarbonylglycyl-(S-4-nitrobenzo-2-oxa-1, 3-diazole)-L-cysteinylglycine as substrate.
