抄録
Forphenicinol stimulated the production of BCG-induced γ-interferon in BCG-sensitized mice as much as 11-fold whereas it did not induce interferon production in unsensitized mice. This stimulatory effect was also observed in mice immuno-suppressed by cyclophosphamide. Furthermore, BCG-induced γ-interferon production was reduced in mice by treatment with an anti-macrophage agent (silica gel), and forphenicinol administration into such mice could augment their interferon production. Transplantation of macrophages from forphenicinol-treated mice into mice injected with silica gel remarkably enhanced the BCG-induced interferon production in the recipients. These results suggest that the stimulatory effect of forphenicinol on BCG-induced γ-interferon production in mice was due to the activation of macrophages.
