PLIPASTATINS: NEW INHIBITORS OF PHOSPHOLIPASE A2, PRODUCED BY BACILLUS CEREUS BMG302-fF67 I. TAXONOMY, PRODUCTION, ISOLATION AND PRELIMINARY CHARACTERIZATION

HAMAO UMEZAWA; TAKAAKI AOYAGI; TAKAAKI NISHIKIORI; AKIRA OKUYAMA; YUJI YAMAGISHI; MASA HAMADA; TOMIO TAKEUCHI

doi:10.7164/antibiotics.39.737

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

PLIPASTATINS: NEW INHIBITORS OF PHOSPHOLIPASE A₂, PRODUCED BY BACILLUS CEREUS BMG302-fF67

I. TAXONOMY, PRODUCTION, ISOLATION AND PRELIMINARY CHARACTERIZATION

HAMAO UMEZAWA, TAKAAKI AOYAGI, TAKAAKI NISHIKIORI, AKIRA OKUYAMA, YUJI YAMAGISHI, MASA HAMADA, TOMIO TAKEUCHI

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1986 Volume 39 Issue 6 Pages 737-744

DOI https://doi.org/10.7164/antibiotics.39.737

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Abstract

Plipastatins have been isolated as part of a program designed to find inhibitors of porcine pancreatic phospholipase A₂. They were purified from fermentation broth of Bacillus cereus BMG3O2-fF67 and finally separated into four fractions by reverse phase HPLC. The respective fractions were designated as plipastatins A1, A2, B1 and B2. Plipastatins also inhibited phospholipases C and D.

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