The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
IN VITRO EVALUATION OF SF-2103A, A NOVEL CARBAPENEM ANTIBIOTIC, AS A β-LACTAMASE INHIBITOR
TOMIZO NIWATAKASHI YOSHIDAATSUSHI TAMURAYUZO KAZUNOSHIGEHARU INOUYETATSUO ITOMICHIO KOJIMA
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1986 Volume 39 Issue 7 Pages 943-955

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Abstract

SF-2103A, a new carbapenem antibiotic, exhibited a broad antibacterial spectrum and a potent inhibitory activity against a wide range of β-lactamases, in particular, against cephalosporinases, with lower I50 values than those displayed by sulbactam and clavulanic acid. Using a fixed combination and checkerboard titration, in vitro synergy against the majority of the β-lactamase-producing strains tested was demonstrated between SF-2103A and various β-lactam antibiotics, especially cefotaxime, ceftizoxime, and cefoperazone. The synergistic effect of SF-2103A was more pronounced than that of sulbactam. The in vitro synergy was also confirmed by bactericidal and bacteriolytic activities and morphological effects.

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