The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
FK-506, A NOVEL IMMUNOSUPPRESSANT ISOLATED FROM A STREPTOMYCES
I. FERMENTATION, ISOLATION, AND PHYSICO-CHEMICAL AND BIOLOGICAL CHARACTERISTICS
TORU KINOHIROSHI HATANAKAMICHISANE HASHIMOTOMICHIHISA NISHIYAMATOSHIO GOTOMASAKUNI OKUHARAMASANOBU KOHSAKAHATSUO AOKIHIROSHI IMANAKA
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1987 Volume 40 Issue 9 Pages 1249-1255

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Abstract

FK-506, a novel immunosuppressant, has been isolated from the fermentation broth of Streptomyces tsukubaensis No. 9993 as colorless prism and the molecular formula was determined as C44H69NO12.H2O. The compound suppressed immune responses in vitro and in vivo with mice. This immunosuppressive effect was more potent than that of ciclosporin.

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