VINIGROL, A NOVEL ANTIHYPERTENSIVE AND PLATELET AGGREGATION INHIBITORY AGENT PRODUCED BY A FUNGUS, VIRGARIA NIGRA I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

TAKESHI ANDO; YASUHISA TSURUMI; NOBUTAKA OHATA; ITSUO UCHIDA; KEIZO YOSHIDA; MASAKUNI OKUHARA

doi:10.7164/antibiotics.41.25

VINIGROL, A NOVEL ANTIHYPERTENSIVE AND PLATELET AGGREGATION INHIBITORY AGENT PRODUCED BY A FUNGUS, VIRGARIA NIGRA

I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

TAKESHI ANDO, YASUHISA TSURUMI, NOBUTAKA OHATA, ITSUO UCHIDA, KEIZO YOSHIDA, MASAKUNI OKUHARA

著者情報

ジャーナルフリー

1988 年 41 巻 1 号 p. 25-30

DOI https://doi.org/10.7164/antibiotics.41.25

詳細

抄録

Vinigrol, produced by a fungal strain identified as Virgaria nigra, was extracted from the cultured mycelium, purified by solvent extraction followed by chromatography on silica gel and then isolated as crystals (C₂₀H₃₄O₃, mp 108°C). Vinigrol decreased arterial blood pressure of anesthetized normotensive rats dose-dependently when administered intravenously. Vinigrol inhibited platelet activating factor and epinephrine induced platelet aggregation.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）