GLIDOBACTINS A, B AND C, NEW ANTITUMOR ANTIBIOTICS I. PRODUCTION, ISOLATION, CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITY

MASAHISA OKA; YUJI NISHIYAMA; SHINICHI OHTA; HIDEO KAMEI; MASATAKA KONISHI; TAKEO MIYAKI; TOSHIKAZU OKI; HIROSHI KAWAGUCHI

doi:10.7164/antibiotics.41.1331

GLIDOBACTINS A, B AND C, NEW ANTITUMOR ANTIBIOTICS

I. PRODUCTION, ISOLATION, CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITY

MASAHISA OKA, YUJI NISHIYAMA, SHINICHI OHTA, HIDEO KAMEI, MASATAKA KONISHI, TAKEO MIYAKI, TOSHIKAZU OKI, HIROSHI KAWAGUCHI

著者情報

ジャーナルフリー

1988 年 41 巻 10 号 p. 1331-1337

DOI https://doi.org/10.7164/antibiotics.41.1331

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抄録

New antitumor antibiotic glidobactins A, B and C were isolated from the cultured broth of a gliding bacterium, Polyangium brachyspomm sp. nov. No. K481-B101. They are novel molecules carrying the common cyclic tripeptide nucleus substituted with different α, β, Υ, -δ-unsaturated fatty acids. Glidobactins exhibit broad inhibitory activity against fungi and yeasts, and prolong the life span of mice inoculated with P388 leukemia cells.

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