The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
THRAZARINE, A NEW ANTITUMOR ANTIBIOTIC
II. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE DETERMINATION
ATSUSHI TAKAHASHI, HIKARU NAKAMURA, DAISHIRO IKEDA, HIROSHI NAGANAWA, TOSHIYUKI KAMEYAMA, SHOGO KURASAWA, YOSHIRO OKAMI, TOMIO TAKEUCHI, YOICHI IITAKA
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JOURNAL FREE ACCESS

1988 Volume 41 Issue 11 Pages 1568-1574

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Abstract
A new antitumor antibiotic thrazarine was soluble in water and positive to anisaldehydesulfuric acid and ninhydrin color reactions. The absolute structure of thrazarine was determined to be O-((3R)-2-diazo-3-hydroxybutyryl)-L-serine by acid hydrolysis, spectroscopic analysis and X-ray crystallographic analysis. Structurally, thrazarine was a new member of azaserine group antibiotics.
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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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