cis-HALOVINYLTHIOACETAMIDO SIDE CHAIN, A NEW EFFECTIVE STRUCTURAL ELEMENT FOR 7β-SUBSTITUTION IN CEPHEM AND OXACEPHEM ANTIBIOTICS

II. 7β-cis-FLUOROVINYLTHIOACETAMINO-7α-METHOXY-1-OXACEPHEMS

Abstract

The synthesis and in vitro activity of 1-oxacephem derivatives having a substituted or a non-substituted cis-fluorovinylthioacetamido side chain at C-7 are described. Of these new 1-oxacephem antibiotics, 2355-S (42a) shows good antibacterial activity against Gram-positive and Gram-negative bacteria, and very favorable pharmacokinetic properties.