SF2446, NEW BENZO[α]NAPHTHACENE QUINONE ANTIBIOTICS
II. THE STRUCTURAL ELUCIDATION
1988 年 41 巻 4 号 p. 425-432
詳細
1988 年 41 巻 4 号 p. 425-432
Structures of new antibiotics SF2446A1, A2, A3, B1, B2 and B3 have been deduced by means of spectral analyses and chemical studies. The structure of SF2446A1 which is a main product of fermentation and has the strongest antimicrobial activity, has been proposed to be 11-(2, 4-di-O-methyl-β-L-rhamnopyranosyl)amino-5, 6, 6a, 14a-tetrahydro-l, 6, 8, 14atetrahydroxy-6a-methoxy-2-methoxycarbonyl-3-methyl-benzo[a]naphthacene-7, 9, 12, 14-tetraone. All of antibiotics have a novel benzo[a]naphthacene quinone skeleton and SF2446A1, A2, B1 and B2 have an N-glycosidic linkage with 2, 4-di-O-methyl-L-rhamnose.
