NEIHUMICIN, A NEW CYTOTOXIC ANTIBIOTIC FROM MICROMONOSPORA NEIHUENSIS

I. THE PRODUCING ORGANISM, FERMENTATION, ISOLATION AND BIOLOGICAL PROPERTIES

Abstract

A new cytotoxic and antifungal antibiotic, neihumicin, was isolated from the culture broth of a soil isolate identified as Micromonospora neihuensis Wu, sp. nov. Neihumicin shows in vitro cytotoxicity against KB tissue culture cells (ED₅₀ 0.94μg/ml) as well as antifungal activity against Saccharomyces cerevisiae ATCC 9763.