The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
SYNTHESIS AND β-LACTAMASE INHIBITORY ACTIVITY OF 9-(2-AMIDOETHENYLTHIO)-9-DEOXY DERIVATIVES OF CLAVULANIC ACID
GERALD BROOKSKENNETH COLEMANJ. SYDNEY DAVIESPAMELA A. HUNTER
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JOURNAL FREE ACCESS

1988 Volume 41 Issue 7 Pages 892-898

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Abstract

The reaction of activated derivatives of clavulanic acid with substituted amidoethenyl thiolates to give 9-(2-amidoethenylthio)-9-deoxy derivatives is described; the antibacterial/synergistic and β-lactamase inhibitory activities of the thioethers and their corresponding sulfoxides and sulfones are compared.

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© Japan Antibiotics Research Association
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