CYTOTOXIC, FUNGICIDAL NUCLEOSIDES FROM BLUE GREEN ALGAE BELONGING TO THE SCYTONEMATACEAE

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Tubercidin, toyocamycin, and the corresponding 5'-α-D-glucopyranose derivatives of the nucleosides are frequently responsible for much of the cytotoxicity and antimycotic activity associated with extracts of cultured cyanophytes belonging to the family Scytonemataceae. The 5'-α-D-glucopyranoses of tubercidin and toyocamycin, for example, are the major cytotoxic and fungicidal nucleosides in Fijian Plectonema radiosum and Hawaiian Tolypothrix tennis, respectively.