NOVEL ANTIFUNGAL ANTIBIOTICS MANIWAMYCINS A AND B I. TAXONOMY OF THE PRODUCING ORGANISM, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL PROPERTIES

MASAHITO NAKAYAMA; YOSHIO TAKAHASHI; HISAKATSU ITOH; KAZUHIRO KAMIYA; MASAMI SHIRATSUCHI; GENJI OTANI

doi:10.7164/antibiotics.42.1535

NOVEL ANTIFUNGAL ANTIBIOTICS MANIWAMYCINS A AND B

I. TAXONOMY OF THE PRODUCING ORGANISM, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL PROPERTIES

MASAHITO NAKAYAMA, YOSHIO TAKAHASHI, HISAKATSU ITOH, KAZUHIRO KAMIYA, MASAMI SHIRATSUCHI, GENJI OTANI

著者情報

ジャーナルフリー

1989 年 42 巻 11 号 p. 1535-1540

DOI https://doi.org/10.7164/antibiotics.42.1535

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抄録

Two antifungal antibiotics maniwamycins A and B were isolated from the culture broth of a strain of actinomycetes, which were classified as Streptomyces prasinopilosus. These antibiotics were isolated by resin absorption and extraction with EtOAc and purified by column chromatography. Both antibiotics were found to be new azoxy substances from their physico-chemical properties. They showed broad antifungal spectra.

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