CISPENTACIN, A NEW ANTIFUNGAL ANTIBIOTIC I. PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE

MASATAKA KONISHI; MAKI NISHIO; KYOICHIRO SAITOH; TAKEO MIYAKI; TOSHIKAZU OKI; HIROSHI KAWAGUCHI

doi:10.7164/antibiotics.42.1749

CISPENTACIN, A NEW ANTIFUNGAL ANTIBIOTIC

I. PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE

MASATAKA KONISHI, MAKI NISHIO, KYOICHIRO SAITOH, TAKEO MIYAKI, TOSHIKAZU OKI, HIROSHI KAWAGUCHI

著者情報

ジャーナルフリー

1989 年 42 巻 12 号 p. 1749-1755

DOI https://doi.org/10.7164/antibiotics.42.1749

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抄録

A new antibiotic, cispentacin, was isolated from the culture broth of a Bacillus cereus strain, L450-B2. The antibiotic is water-soluble and amphoteric; its structure was determined by spectroscopic analysis and chemical synthesis to be (1R, 2S)-2-aminocyclopentane-l-carboxylic acid. Cispentacin demonstrated only weak in vitro activity against certain fungi but strong protection of mice from lethal infection of Candida albicans A9540.

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