MYROCIN C, A NEW DITERPENE ANTITUMOR ANTIBIOTIC FROM MYROTHECIUM VERRUCARIA

I. TAXONOMY OF THE PRODUCING STRAIN, FERMENTATION, ISOLATION AND BIOLOGICAL PROPERTIES

Abstract

A new diterpene antitumor antibiotic, myrocin C, has been isolated from the culture filtrate of a soil fungus, Myrothecium verrucaria strain No. 55. The antibiotic was effective against Gram-positive bacteria, fungi and yeasts, and prolonged the life span of mice bearing Ehrlich ascites carcinoma.