9, 11-CYCLIC ACETAL DERIVATIVES OF (9S)-9-DIHYDROERYTHROMYCIN A
1989 年 42 巻 2 号 p. 293-298
詳細
1989 年 42 巻 2 号 p. 293-298
A series of 9, 11-cyclic acetal derivatives of (9S)-9-dihydroerythromycin A (4) have been prepared and their antibacterial activities compared to those of erythromycin A and 9-dihydroerythromycin A. Many of the cyclic acetal derivatives showed better antibacterial activity than their parent 4. In particular, the acetaldehyde acetal (9-O, 11-O-ethylidene-9-dihydroerythromycin A) (8b) showed good antibacterial activity in comparison with erythromycin A but was not sufficiently improved in vivo to warrant progression.
