HATOMAMICIN (YL-0358M-A), A NEW ALKALOID ANTIBIOTIC: FERMENTATION, ISOLATION, STRUCTURE AND BIOLOGICAL PROPERTIES

HARUMITSU IMAI; SHIGEO FUJITA; KENICHI SUZUKI; MOTO MORIOKA; TATSUHIRO TOKUNAGA; MINORU SHIMIZU; SHIGENOBU KADOTA; TOSHIO FURUYA; TAKESHI SAITO

doi:10.7164/antibiotics.42.1043

HARUMITSU IMAI, SHIGEO FUJITA, KENICHI SUZUKI, MOTO MORIOKA, TATSUHIRO TOKUNAGA, MINORU SHIMIZU, SHIGENOBU KADOTA, TOSHIO FURUYA, TAKESHI SAITO

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ジャーナルフリー

1989 年 42 巻 7 号 p. 1043-1048

DOI https://doi.org/10.7164/antibiotics.42.1043

詳細

抄録

Hatomamicin, a new alkaloid antibiotic, was isolated from the culture filtrate of a strain of Saccharopolyspora. The antibiotic was extracted with EtOAc and purified by silica gel column chromatography. The free alkaloid was obtained as pale yellowish prisms from CH₃CN solution. It exhibits antimicrobial activity against Gram-positive organisms. The apparent molecular formula of hatomamicin was determined to be C₂₂H₃₁NO₅. The structure has been established by a combination of spectroscopic and X-ray crystallographic studies.

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