A NEW IMMUNOMODULATOR, FR-901235

TOSHIHIRO SHIBATA; MOTOAKI NISHIKAWA; YASUHISA TSURUMI; SHIGEHIRO TAKASE; HIROSHI TERANO; MASANOBU KOHSAKA

doi:10.7164/antibiotics.42.1356

TOSHIHIRO SHIBATA, MOTOAKI NISHIKAWA, YASUHISA TSURUMI, SHIGEHIRO TAKASE, HIROSHI TERANO, MASANOBU KOHSAKA

著者情報

ジャーナルフリー

1989 年 42 巻 9 号 p. 1356-1361

DOI https://doi.org/10.7164/antibiotics.42.1356

詳細

抄録

FR-901235 is a new type of immunoactive substance produced by an imperfect fungus, Paecilomyces carneus F-4882.
The mitogen-induced lymphocyte proliferation which had been suppressed by addition of immunosuppressive factor, was restored to a normal level by the addition of FR-901235. Furthermore, the subsequent administration of FR-901235 partially restored the impaired delayed-type hypersensitivity to sheep red blood cells in tumor-bearing mice.

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