FR109615, A NEW ANTIFUNGAL ANTIBIOTIC FROM STREPTOMYCES SETONII TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITY

TOSHIRO IWAMOTO; EISAKU TSUJII; MASAMI EZAKI; AKIHIKO FUJIE; SEIJI HASHIMOTO; MASAKUNI OKUHARA; MASANOBU KOHSAKA; HIROSHI IMANAKA; KOHJI KAWABATA; YOSHIKO INAMOTO; KAZUO SAKANE

doi:10.7164/antibiotics.43.1

FR109615, A NEW ANTIFUNGAL ANTIBIOTIC FROM STREPTOMYCES SETONII

TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITY

TOSHIRO IWAMOTO, EISAKU TSUJII, MASAMI EZAKI, AKIHIKO FUJIE, SEIJI HASHIMOTO, MASAKUNI OKUHARA, MASANOBU KOHSAKA, HIROSHI IMANAKA, KOHJI KAWABATA, YOSHIKO INAMOTO, KAZUO SAKANE

著者情報

ジャーナルフリー

1990 年 43 巻 1 号 p. 1-7

DOI https://doi.org/10.7164/antibiotics.43.1

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抄録

FR109615, a new antibiotic active against Candida, was isolated from Streptomyces setonii No. 7562. Based on the spectroscopic data, the structure of FR109615 was elucidated as cis-2-aminocyclopentane-1-carboxylic acid (1). The compound showed the excellent in vivo efficacy in a generalized infection test of mice.

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