A NEW ANTIPSEUDOMONAL CEPHALOSPORIN CP6162 AND ITS CONGENERS

抄録

The synthesis and biological activity of a series of 3-[2-(5-hydroxy-4-pyridon-2-yl)ethenyl]cephalosporin derivatives are described. They showed very potent activity against Gram-negative bacteria, especially Pseudomonas Aeruginosa. (6R, 7R)-7-[(Z]-2-(2-Aminothiazol-4-yl)-2-(l-carboxy-l-methyl)-ethoxyiminoacetamido]-3-[(Z]-2-(l, 5-dihydroxy-4-pyridon-2-yl)ethenyl]ceph-3-em-4-carboxylic acid, CP6162 (8e), was selected for further evaluation as an antipseudomonal chemotherapeutic agent.