THE KAPURIMYCINS, NEW ANTITUMOR ANTIBIOTICS PRODUCED BY STREPTOMYCES PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE DETERMINATION

MAYUMI YOSHIDA; MITSUNOBU HARA; YUTAKA SAITOH; HIROSHI SANO

doi:10.7164/antibiotics.43.1519

THE KAPURIMYCINS, NEW ANTITUMOR ANTIBIOTICS PRODUCED BY STREPTOMYCES

PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE DETERMINATION

MAYUMI YOSHIDA, MITSUNOBU HARA, YUTAKA SAITOH, HIROSHI SANO

著者情報

ジャーナルフリー

1990 年 43 巻 12 号 p. 1519-1523

DOI https://doi.org/10.7164/antibiotics.43.1519

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抄録

The kapurimycins A1, A2 and A3 were revealed to be new antitumor antibiotics with molecular formula of C₂₇H₂₆O₉, C₂₆H₂₄O₉ and C₂₇H₂₄O₉, respectively. The structures of the kapurimycins were determined by NMR spectroscopic analysis. The kapurimycins are new class of polycyclic microbial metabolites having the tetrahydroanthra-γ-pyrone skeleton and the β, γ-unsaturated δ-keto carboxylic acid structure. The individual components of the kapurimycins differ from one another in the side chain at the pyrone ring of the molecule.

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