PUMILACIDIN, A COMPLEX OF NEW ANTIVIRAL ANTIBIOTICS

PRODUCTION, ISOLATION, CHEMICAL PROPERTIES, STRUCTURE AND BIOLOGICAL ACTIVITY

Abstract

New antibiotic pumilacidins A, B, C, D, E, F and G were isolated from the culture broth of a strain of Bacillus pumilus. They are cyclic acylheptapeptide composed of a β-hydroxy fatty acid, two L-leucine, two D-leucine, L-glutamic acid, L-aspartic acid and L-isoleucine (or L-valine). Pumilacidin components were inhibitory to herpes simplex virus type 1 and H⁺, K⁺-ATPase and demonstrated antiulcer activity in rat.