STUDIES ON NEW DEHYDROPEPTIDASE INHIBITORS III. BIOLOGICAL PROPERTIES OF WS1358A1

SEIJI HASHIMOTO; HIDETSUGU MURAI; KUMIKO NITTA; AKIHIKO FUJIE; MASAKUNI OKUHARA; MASANOBU KOHSAKA; HIROSHI IMANAKA

doi:10.7164/antibiotics.43.281

STUDIES ON NEW DEHYDROPEPTIDASE INHIBITORS

III. BIOLOGICAL PROPERTIES OF WS1358A1

SEIJI HASHIMOTO, HIDETSUGU MURAI, KUMIKO NITTA, AKIHIKO FUJIE, MASAKUNI OKUHARA, MASANOBU KOHSAKA, HIROSHI IMANAKA

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JOURNAL FREE ACCESS

1990 Volume 43 Issue 3 Pages 281-285

DOI https://doi.org/10.7164/antibiotics.43.281

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Abstract

WS1358A1, a novel inhibitor of renal dehydropeptidase (DHP), augmented the urinary recovery of a carbapenem antibiotic imipenem and improved its protective effect in experimental infections when simultaneously administered to mice with the antibiotic.
WS1358A1 was a competitive DHP inhibitor with a Ki value of 1.6×10^-7M.

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