The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
STUDIES ON NEW DEHYDROPEPTIDASE INHIBITORS
III. BIOLOGICAL PROPERTIES OF WS1358A1
SEIJI HASHIMOTO, HIDETSUGU MURAI, KUMIKO NITTA, AKIHIKO FUJIE, MASAKUNI OKUHARA, MASANOBU KOHSAKA, HIROSHI IMANAKA
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JOURNAL FREE ACCESS

1990 Volume 43 Issue 3 Pages 281-285

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Abstract
WS1358A1, a novel inhibitor of renal dehydropeptidase (DHP), augmented the urinary recovery of a carbapenem antibiotic imipenem and improved its protective effect in experimental infections when simultaneously administered to mice with the antibiotic.
WS1358A1 was a competitive DHP inhibitor with a Ki value of 1.6×10-7M.
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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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