PUMILACIDIN, A COMPLEX OF NEW ANTIVIRAL ANTIBIOTICS PRODUCTION, ISOLATION, CHEMICAL PROPERTIES, STRUCTURE AND BIOLOGICAL ACTIVITY

NOBUAKI NARUSE; OSAMU TENMYO; SEIKICHI KOBARU; HIDEO KAMEI; TAKEO MIYAKI; MASATAKA KONISHI; TOSHIKAZU OKI

doi:10.7164/antibiotics.43.267

PUMILACIDIN, A COMPLEX OF NEW ANTIVIRAL ANTIBIOTICS

PRODUCTION, ISOLATION, CHEMICAL PROPERTIES, STRUCTURE AND BIOLOGICAL ACTIVITY

NOBUAKI NARUSE, OSAMU TENMYO, SEIKICHI KOBARU, HIDEO KAMEI, TAKEO MIYAKI, MASATAKA KONISHI, TOSHIKAZU OKI

著者情報

ジャーナルフリー

1990 年 43 巻 3 号 p. 267-280

DOI https://doi.org/10.7164/antibiotics.43.267

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抄録

New antibiotic pumilacidins A, B, C, D, E, F and G were isolated from the culture broth of a strain of Bacillus pumilus. They are cyclic acylheptapeptide composed of a β-hydroxy fatty acid, two L-leucine, two D-leucine, L-glutamic acid, L-aspartic acid and L-isoleucine (or L-valine). Pumilacidin components were inhibitory to herpes simplex virus type 1 and H⁺, K⁺-ATPase and demonstrated antiulcer activity in rat.

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