A NOVEL ANTIFUNGAL ANTIBIOTIC, FR-900848 I. PRODUCTION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

MASARU YOSHIDA; MASAMI EZAKI; MICHIZANE HASHIMOTO; MICHIO YAMASHITA; NOBUHARU SHIGEMATSU; MASAKUNI OKUHARA; MASANOBU KOHSAKA; KOKI HORIKOSHI

doi:10.7164/antibiotics.43.748

A NOVEL ANTIFUNGAL ANTIBIOTIC, FR-900848

I. PRODUCTION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

MASARU YOSHIDA, MASAMI EZAKI, MICHIZANE HASHIMOTO, MICHIO YAMASHITA, NOBUHARU SHIGEMATSU, MASAKUNI OKUHARA, MASANOBU KOHSAKA, KOKI HORIKOSHI

Author information

MASARU YOSHIDA
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
Present address: Technological Development Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
MASAMI EZAKI
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
MICHIZANE HASHIMOTO
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
MICHIO YAMASHITA
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
NOBUHARU SHIGEMATSU
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
MASAKUNI OKUHARA
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
MASANOBU KOHSAKA
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
KOKI HORIKOSHI
Department of Bio-Engineering, Tokyo Institute of Technology

JOURNAL FREE ACCESS

1990 Volume 43 Issue 7 Pages 748-754

DOI https://doi.org/10.7164/antibiotics.43.748

Details

Abstract

Streptoverticillium fervens produced a new antibiotic, FR-900848, which has a high specific activity against filamentous fungi. Purified by solvent extraction and column chromatography, the compound appears as colorless crystals. Its structure is C₃₂H₄₃N₃O₆, which consists of 5'-amino-5'-deoxy-5, 6-dihydrouridine with an unsaturated fatty acid having unprecedented four serial and one isolated cyclopropane rings.

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