JANTHINOCINS A, B AND C, NOVEL PEPTIDE LACTONE ANTIBIOTICS PRODUCED BY JANTHINOBACTERIUM LIVIDUM I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL CHARACTERIZATION

JOSEPH O'SULLIVAN; JOHN MCCULLOUGH; JANICE H. JOHNSON; DANIEL P. BONNER; JUNIUS C. CLARK; LORETTA DEAN; WILLIAM H. TREJO

doi:10.7164/antibiotics.43.913

JANTHINOCINS A, B AND C, NOVEL PEPTIDE LACTONE ANTIBIOTICS PRODUCED BY JANTHINOBACTERIUM LIVIDUM

I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL CHARACTERIZATION

JOSEPH O'SULLIVAN, JOHN MCCULLOUGH, JANICE H. JOHNSON, DANIEL P. BONNER, JUNIUS C. CLARK, LORETTA DEAN, WILLIAM H. TREJO

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JOURNAL FREE ACCESS

1990 Volume 43 Issue 8 Pages 913-919

DOI https://doi.org/10.7164/antibiotics.43.913

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Abstract

Janthinocins A, B and C are novel antibacterial agents produced by Janthinobacterium lividum. They were isolated from fermentation broths and characterized by UV, IR, NMR and mass spectroscopy. They are cyclic decapeptide lactones with marked activity against aerobic and anaerobic Gram-positive bacteria and are 2 to 4 times more potent in vitro than vancomycin. Janthinocins A and B were also found to be effective in a Staphylococcus aureus systemic infection in mice.

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