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I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL CHARACTERIZATION
JOSEPH O'SULLIVAN, JOHN MCCULLOUGH, JANICE H. JOHNSON, DANIEL P. BONNE ...
1990 Volume 43 Issue 8 Pages
913-919
Published: August 25, 1990
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Janthinocins A, B and C are novel antibacterial agents produced by
Janthinobacterium lividum. They were isolated from fermentation broths and characterized by UV, IR, NMR and mass spectroscopy. They are cyclic decapeptide lactones with marked activity against aerobic and anaerobic Gram-positive bacteria and are 2 to 4 times more potent
in vitro than vancomycin. Janthinocins A and B were also found to be effective in a
Staphylococcus aureus systemic infection in mice.
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II. STRUCTURE ELUCIDATION
JANICE H. JOHNSON, ADRIENNE A. TYMIAK, MARK S. BOLGAR
1990 Volume 43 Issue 8 Pages
920-930
Published: August 25, 1990
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The structures of janthinocins A, B and C, three novel macrocyclic peptide lactone antibiotics isolated from fermentations of
Janthinobacterium lividum, were determined. The janthinocins are of particular interest because they contain three amino acid residues that have not previously been reported in natural products: Each contains
erythro-β-hydroxy-D-leucine while janthinocins A and B also contain β-hydroxytryptophan and β-ketotryptophan, respectively.
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ISOLATION, PURIFICATION AND STRUCTURE DETERMINATION
STEPHEN J. Box, ANNA L. ELSON, MARTIN L. GILPIN, DAVID J. WINSTANLEY
1990 Volume 43 Issue 8 Pages
931-937
Published: August 25, 1990
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Two glycopeptide antibiotics MM 47761 and MM 49721 have been isolated from
Amycolatopsis orientalis NCIB 12608. Fermentation conditions for their production, and methods for their isolation are described. The metabolites have been characterised by physico-chemical and biological properties and the structure determined by a combination of chemical degradation, COSY and NOE NMR studies. Both metabolites showed good antibacterial activity against Gram-positive organisms.
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I. TAXONOMY, FERMENTATION, ISOLATION AND PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES
KOHTAROU FUNAISHI, KENJI KAWAMURA, FUMIO SATOH, MUNEYO HIRAMATSU, MASA ...
1990 Volume 43 Issue 8 Pages
938-947
Published: August 25, 1990
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Antibiotics 6108 A
1, B, C and D, a new series of analogues of rosaramicin, were found together with rosaramicin, juvenimicin A
4 and M-4365 A
1 from the cultured broth of strain BA06108 which was assigned to be a new species of
Micromonospora. 6108 A
1 and C showed inhibitory activity against Gram-positive and some Gram-negative bacteria as potent as rosaramicin and exhibited low acute toxicity in mice. However, 6108 B showed less potent antimicrobial activity and 6108 D showed higher toxicity than those two antibiotics.
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I. PRODUCTION, ISOLATION, CHARACTERIZATION AND BIOLOGICAL PROPERTIES
AKIRA ITOH, JUNKO IDO, YUKIMASA IWAMOTO, EIICHI GOSHIMA, TOYOHIKO MIKI ...
1990 Volume 43 Issue 8 Pages
948-955
Published: August 25, 1990
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A new polyene macrolide antibiotic, YS-822A was isolated from the culture filtrate of a mutant strain H-8 of
Streptoverticillium eurocidicum var.
asterocidicus S-822. Whereas the original S-822 strain produced not only YS-822 substances but also teleocidin as by-product which is well-known as a strong carcinogenic promotor, the mutagenized H-8 strain produced the antibiotic with only a trace amount of teleocidin. Chemical and biological characterizations of the antibiotic revealed that YS-822A (molecular formula: C
37H
59NO
14) is a new polyene macrolide with a wide antifungal spectrum and a low acute toxicity.
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I. TAXONOMY OF PRODUCING ORGANISM, FERMENTATION AND BIOLOGICAL ACTIVITY
KIN SING LAM, GRACE A. HESLER, JACQUELINE M. MATTEI, STEPHEN W. MAMBER ...
1990 Volume 43 Issue 8 Pages
956-960
Published: August 25, 1990
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Strain C39108-P210-51 (ATCC 53653), an actinomycete isolated from a soil sample collected in India, was found to produce a new antitumor antibiotic, designated himastatin. Taxonomic studies on its morphological, cultural and physiological characteristics identified this producing strain as
Streptomyces hygroscopicus C39108-P210-51. Himastatin shows antimicrobial activity against Gram-positive bacteria but it is inactive against Gram-negative bacteria. Himastatin prolongs the life span of mice inoculated with P388 leukemia and B16 melanoma cells.
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II. ISOLATION AND CHARACTERIZATION
JOHN E. LEET, DANIEL R. SCHROEDER, BALA S. KRISHNAN, JAMES A. MATSON
1990 Volume 43 Issue 8 Pages
961-966
Published: August 25, 1990
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The novel antitumor antibiotic himastatin was isolated from cultured broth of
Streptomyces hygroscopicus (ATCC 53653) and purified by vacuum liquid chromatography, column chromatography, and crystallization. Degradation and spectroscopic studies have shown that himastatin contains valine, leucine, threonine, α-hydroxyisovaleric acid, 5-hydroxypiperazic acid and a dimeric hexahydropyrroloindole system.
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MASAHISA OKA, HIDEO KAMEI, YASUTARO HAMAGISHI, KOJI TOMITA, TAKEO MIYA ...
1990 Volume 43 Issue 8 Pages
967-976
Published: August 25, 1990
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A novel complex of isotetracenone (angucyclinone) group antibiotics was discovered from the cultured broth of
Streptomyces griseorubiginosus No. Q144-2. The antibiotic consisted of six related factors, designated rubiginones A
1, A
2, B
1, B
2, C
1 and C
2. They significantly potentiated cytotoxicity of vincristine (VCR) against VCR-resistant P388 leukemia and Moser cells.
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OSAMU HARA, C. RICHARD HUTCHINSON
1990 Volume 43 Issue 8 Pages
977-991
Published: August 25, 1990
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DNA containing genes for midecamycin(Mdm)-resistance was cloned from
Streptomyces mycarofaciens ATCC 21454 (
mdmA gene),
Streptomyces lividans 66 (
Irm gene) and
Streptomyces coelicolor A3(2). The phenotype imparted to
S. lividans and
Streptomyces griseofuscus transformants by the cloned DNA segments indicates that they encode an MLS-type of resistance activity. The
mdmA and
Irm genes could be distinguished by the phenotype they conferred in
S. lividans and
S. griseofuscus, whereas the
S. lividans Irm and
S. coelicolor MLS genes appear to be identical on the basis of their restriction maps and behavior in
S. lividans and
S. griseofuscus. The DNA sequence of a 1.4-kb
BamH I DNA fragment containing the
mdmA gene indicates the presence of one complete
orf whose deduced product exhibits a high similarity to the deduced product of the
Streptomyces thermotolerans carB gene and several other bacterial MLS-resistance genes.
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STEVEN L. GOLDBERG, JORGE G. ROMERO, YASHWANT M. DEO
1990 Volume 43 Issue 8 Pages
992-999
Published: August 25, 1990
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We cloned DNA fragments of sisomicin-producing
Micromonospora inyoensis1) into
Streptomyces plasmid vectors and identified
Streptomyces lividans TK24 transformants expressing the
M. inyoensis sisomicin-resistance (
sisA) gene. The
sisA gene was compared to the previously reported
Micromonospora purpurea Kan-Gen (kanamycin-gentamicin)-resistance gene
2). While the restriction endonuclease digestion patterns of the two determinants appear to be divergent, the genes are nonetheless closely related, based on similar patterns and levels of aminoglycoside-resistance and their ability to cross-hybridize under stringent conditions. We have transformed recombinant plasmid pMD5-2, which carries the
sisA gene, into our
M. purpurea gentamicin-production strain and determined that gentamicin biosynthesis was not improved.
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KAZURO SHIOMI, HIRONOBU IINUMA, HIROSHI NAGANAWA, MASA HAMADA, SEIKO H ...
1990 Volume 43 Issue 8 Pages
1000-1005
Published: August 25, 1990
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II. STRUCTURE DETERMINATION
SHIGERU NAKAJIMA, KATSUHISA KOJIRI, HAJIME MORISHIMA, MASANORI OKANISH ...
1990 Volume 43 Issue 8 Pages
1006-1009
Published: August 25, 1990
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XXXXIII OUDEMANSIN X, A NEW ANTIFUNGAL E-β-METHOXYACRYLATE FROM OUDEMANSIELLA RADICATA (RELHAN EX FR.) SING
TIMM ANKE, ANDREAS WERLE, MONIKA BROSS, WOLFGANG STEGLICH
1990 Volume 43 Issue 8 Pages
1010-1011
Published: August 25, 1990
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III. ISOLATION AND CHARACTERIZATION OF ENACTIN CONGENERS
KATSUMI YAMAMOTO, YOSHIKAZU SHIINOKI, MAKI NISHIO, YASUCHIKA MATSUDA, ...
1990 Volume 43 Issue 8 Pages
1012-1017
Published: August 25, 1990
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HIDEO KAMEI, MASAHISA OKA, YASUTARO HAMAGISHI, KOJI TOMITA, MASATAKA K ...
1990 Volume 43 Issue 8 Pages
1018-1020
Published: August 25, 1990
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YOSHIO INOUYE, KEIKO OOGOSE, SHOSHIRO NAKAMURA
1990 Volume 43 Issue 8 Pages
1021-1027
Published: August 25, 1990
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MASATOSHI KAKUSHIMA, MAKI NISHIO, KEI-ICHI NUMATA, MASATAKA KONISHI, T ...
1990 Volume 43 Issue 8 Pages
1028-1030
Published: August 25, 1990
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NOBUFUSA SERIZAWA, KAORI NAKAHARA, TATSUJI MATSUOKA
1990 Volume 43 Issue 8 Pages
1031-1033
Published: August 25, 1990
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SATOSHI OMURA, YOSHITAKE TANAKA, ISAO KANAYA, MAYUMI SHINOSE, YOKO TAK ...
1990 Volume 43 Issue 8 Pages
1034-1036
Published: August 25, 1990
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MICHIO ICHIMURA, TATSUHIRO OGAWA, KEI-ICHI TAKAHASHI, EIJI KOBAYASHI, ...
1990 Volume 43 Issue 8 Pages
1037-1038
Published: August 25, 1990
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NAOKI ASANO, YUKIHIKO KAMEDA, KATSUHIKO MATSUI, SATOSHI HORII, HIROSHI ...
1990 Volume 43 Issue 8 Pages
1039-1041
Published: August 25, 1990
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DAVID F. CORBETT, COLIN H. FRYDRYCH, ROBERT SOUTHGATE, MICHAEL J. BASK ...
1990 Volume 43 Issue 8 Pages
1042-1044
Published: August 25, 1990
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SHIN-ICHI ITO, GUSTAV GILLJAMS, BRITTA WAHREN, HANS WIGZELL, NAOKI YAM ...
1990 Volume 43 Issue 8 Pages
1045-1046
Published: August 25, 1990
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KENJI SAKAGAMI, KUNIO ATSUMI, ATSUSHI TAMURA, TAKASHI YOSHIDA, KEN NIS ...
1990 Volume 43 Issue 8 Pages
1047-1050
Published: August 25, 1990
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UWE GOTTSCHALK, AXEL MAIBÜCHER, HENNING MENKE, WOLFGANG KÖHN ...
1990 Volume 43 Issue 8 Pages
1051-1054
Published: August 25, 1990
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JACK E. BALDWIN, JULIETTE W. BIRD, ROBERT A. FIELD, NIAMH M. O'CALLAGH ...
1990 Volume 43 Issue 8 Pages
1055-1057
Published: August 25, 1990
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