抄録
The structure of purpactins, novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors, was determined by spectroscopic analyses. Purpactin A was deduced to be 3-l'-acetoxy-11-hydroxy-4- methoxy-9-methyl-3'-methylbutyl-5H, 7H-dibenzo[b, g]-l, 5-dioxocin-5-one, purpactin B was 5-1"- acetoxy-6'-hydroxyrnethyl-4-methoxy-4'-methyl-3"-methylbutyl-spiro[benzofuran-2, r-cyclohex a- 3', 5'-diene]-2', 3(2H)-dione and purpactin C was 5-l"-acetoxy-6'-formyl-4-methoxy-4'-methyl-3"- methylbutyl-spiro[benzofuran-2, 1'-cyclohexa-3', 5'-diene]-2', 3(2H)-dione. Purpactin A was attributed to 1'-O-acetylpenicillide.
