ISOLATION AND CHARACTERIZATION OF PHOSMIDOSINE A NEW ANTIFUNGAL NUCLEOTIDE ANTIBIOTIC

Abstract

A new nucleotide antibiotic, phosmidosine was isolated from a culture filtrate of a newly isolated streptomycete identified as Streptomyces sp. RK-16. HRFAB-MS and elemental analysis established the molecular formula of C₁₆H₂₄N₇O₈P. ¹H, ¹³C and ³¹P NMR indicated the presence of a methyl phosphate group and UV spectra were similar to those of 8-hydroxyadenosine. The antibiotic inhibited spore formation of Botrytis cinerea at the concentration of 0.25 μg/ml.