MM 55266 AND MM 55268, GLYCOPEPTIDE ANTIBIOTICS PRODUCED BY A NEW STRAIN OF Amycolatopsis

ISOLATION, PURIFICATION AND STRUCTURE DETERMINATION

Abstract

Two novel glycopeptide antibiotics MM 55266 and MM 55268 containing fatty acid acyl functions, and of molecular formula C₈₆H₈₉N₈O₃₅Cl₅ and C₈₇H₉₁N₈O₃₅C₁₅, respectively, have been isolated and identified from a complex produced by Amycolatopsis sp. NCIB 40089. Fermentation conditions for their production, and methods for their isolation are described. Structures have been deduced by use of COSY and NOE NMR techniques and supported by chemical degradation studies. Both glycopeptides possessed good antibacterial activity against Gram-positive organisms.