A NOVEL HEPATOPROTECTIVE γ-LACTONE, MH-031 I. DISCOVERY, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND STRUCTURAL ELUCIDATION

YUMIKO ITOH; HIROSHI SHIMURA; MAYUMI ITO; NAOHARU WATANABE; MICHIO YAMAGISHI; MASAHARU TAMAI; KAZUNORI HANADA

doi:10.7164/antibiotics.44.832

A NOVEL HEPATOPROTECTIVE γ-LACTONE, MH-031

I. DISCOVERY, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND STRUCTURAL ELUCIDATION

YUMIKO ITOH, HIROSHI SHIMURA, MAYUMI ITO, NAOHARU WATANABE, MICHIO YAMAGISHI, MASAHARU TAMAI, KAZUNORI HANADA

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JOURNAL FREE ACCESS

1991 Volume 44 Issue 8 Pages 832-837

DOI https://doi.org/10.7164/antibiotics.44.832

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Abstract

A new subspecies of Streptomyces rishiriensis A-5969 (PERM BP-1394) was isolated and shown to produce a novel α, β-unsaturated γ-lactone derivative, MH-031, which exhibited hepatoprotective activity in primary cultured rat hepatocytes intoxicated with D-galactosamine.

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