MICROBIAL TRANSFORMATION OF IMMUNOSUPPRESSIVE COMPOUNDS
I. DESMETHYLATION OF FK506 AND IMMUNOMYCIN (FR 900520) BY Actinoplanes sp. ATCC 53771
1992 年 45 巻 1 号 p. 118-123
詳細
1992 年 45 巻 1 号 p. 118-123
The immimosuppressants FK506 and FR 900520 were desmethylated by Actinoplanes sp. ATCC 53771 to yield various O-desmethylated products. The products were isolated and purified by solvent extraction and HPLC chromatography, and identified by NMR and MS spectroscopy.
