The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ANTIBIOTICS FROM BASIDIOMYCETES XLI
CLAVICORONIC ACID, A NOVEL INHIBITOR OF REVERSE TRANSCRIPTASES FROM Clavicorona pyxidata (PERS. EX FR.) DOTY
GERHARD ERKELTIMM ANKEALBERTO GIMENEZWOLFGANG STEGLICH
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1992 Volume 45 Issue 1 Pages 29-37

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Abstract

A novel inhibitor of RNA-directed DNA-polymerases was isolated from fermentations of Clavicorona pyxidata. Its structure was elucidated by spectroscopic methods. Clavicoronic acid (1) is a noncompetitive inhibitor of avian myeloblastosis virus (Ki 130 μM) and Moloney murine leukemia virus (Ki 68μM) reverse transcriptases. In permeabilized cells and isolated nucleic DNA- and RNA-synthesis are not affected. Clavicoronic acid markedly inhibits the multiplication of vesicular stomatitis virus in baby hamster kidney cells by interfering with this virus's RNA-directed RNA-polymerase. 1 exhibits no cytotoxic and very weak antimicrobial activities.

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