MATLYSTATINS, NEW INHIBITORS OF TYPEIV GOLLAGENASES FROM Actinomadura atramentaria II. BIOLOGICAL ACTIVITIES

KAZUHIKO TANZAWA; MIYUKI ISHII; TAKESHI OGITA; KOHEI SHIMADA

doi:10.7164/antibiotics.45.1733

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

MATLYSTATINS, NEW INHIBITORS OF TYPEIV GOLLAGENASES FROM Actinomadura atramentaria

II. BIOLOGICAL ACTIVITIES

KAZUHIKO TANZAWA, MIYUKI ISHII, TAKESHI OGITA, KOHEI SHIMADA

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JOURNAL FREE ACCESS

1992 Volume 45 Issue 11 Pages 1733-1737

DOI https://doi.org/10.7164/antibiotics.45.1733

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Abstract

Matlystatin A, the main component of matlystatins, inhibits 92kDa and 72kDa typeIV collagenases with IC₅₀ values of 0.3μM and 0.56μM, respectively, while 7- to 11-fold greater concentrations are required to inhibit thermolysin and aminopeptidase M. The inhibition is reversible and competitive with respect to gelatin. It inhibits the invasion of basement membrane Matrigel by human fibrosarcoma HT1080 dose-dependently with an IC₅₀ value of 21.6μM.

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