PNEUMOCANDINS FROM Zalerion arboricola I. DISCOVERY AND ISOLATION

ROBERT E. SCHWARTZ; DAVID F. SESIN; HENRY JOSHUA; KENNETH E. WILSON; AUGUST J. KEMPF; KENT A. GOKLEN; DANIEL KUEHNER; PATRICK GAILLIOT; CAROLYN GLEASON; RAYMOND WHITE; EDWARD INAMINE; GERALD BILLS; PETER SALMON; LAURETTA ZITANO

doi:10.7164/antibiotics.45.1853

PNEUMOCANDINS FROM Zalerion arboricola

I. DISCOVERY AND ISOLATION

ROBERT E. SCHWARTZ, DAVID F. SESIN, HENRY JOSHUA, KENNETH E. WILSON, AUGUST J. KEMPF, KENT A. GOKLEN, DANIEL KUEHNER, PATRICK GAILLIOT, CAROLYN GLEASON, RAYMOND WHITE, EDWARD INAMINE, GERALD BILLS, PETER SALMON, LAURETTA ZITANO

著者情報

ROBERT E. SCHWARTZ
Merck Research Laboratories
DAVID F. SESIN
Merck Research Laboratories
HENRY JOSHUA
Merck Research Laboratories
KENNETH E. WILSON
Merck Research Laboratories
AUGUST J. KEMPF
Merck Research Laboratories
KENT A. GOKLEN
Merck Research Laboratories
DANIEL KUEHNER
Merck Research Laboratories
PATRICK GAILLIOT
Merck Research Laboratories
CAROLYN GLEASON
Merck Research Laboratories
RAYMOND WHITE
Merck Research Laboratories
EDWARD INAMINE
Merck Research Laboratories
GERALD BILLS
Merck Research Laboratories
PETER SALMON
Merck Research Laboratories
LAURETTA ZITANO
Merck Research Laboratories

ジャーナルフリー

1992 年 45 巻 12 号 p. 1853-1866

DOI https://doi.org/10.7164/antibiotics.45.1853

詳細

抄録

HPLC bioautography of the directed biosynthesis of Zalerion arboricola led to the discovery of pneumocandin B₀ (L-688, 786), a new antifungal and anti-Pneumocystis carinii lipopeptide. Isolation techniques were developed to separate this component from pneumocandin A₀ (L-671, 329) in fermentations of a mutant of Zalerion arboricola. A number of related compounds were also isolated, which differ from pneurnocandins A₀ and B₀ in the hydroxylation patterns on the ornithine, homotyrosine, and proline.

責任著者(Corresponding author)

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