SYNTHESIS AND ACTIVITY OF C-21 ALKYLAMINO DERIVATIVES OF (9R)-ERYTHROMYCYLAMINE

PAUL A. LARTEY; SHARI L. DENINNO; RAMIN FAGHIH; DWIGHT J. HARDY; JACOB J. CLEMENT; JACOB J. PLATTNER

doi:10.7164/antibiotics.45.380

PAUL A. LARTEY, SHARI L. DENINNO, RAMIN FAGHIH, DWIGHT J. HARDY, JACOB J. CLEMENT, JACOB J. PLATTNER

著者情報

ジャーナルフリー

1992 年 45 巻 3 号 p. 380-385

DOI https://doi.org/10.7164/antibiotics.45.380

詳細

抄録

Novel analogs of (9R)-9-deoxo-9-(N, N-dimethylamino)erythromycin A bearing N-alkylamino substituents at the C-21 position were synthesized. These compounds retained antibacterial activity. The C-21 N, N-dimethylamino analog showed a modest improvement in activity against some Gram-negative bacteria.

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