NEW POLYENIC ANTIBIOTICS ACTIVE AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA IV. STRUCTURAL ELUCIDATION OF ENACYLOXIN IIa

TOSHIHIKO WATANABE; TAKEYOSHI SUGIYAMA; MASAHIRO TAKAHASHI; JUN SHIMA; KYOHEI YAMASHITA; KAZUO IZAKI; KAZUO FURIHATA; HARUO SETO

doi:10.7164/antibiotics.45.470

NEW POLYENIC ANTIBIOTICS ACTIVE AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA

IV. STRUCTURAL ELUCIDATION OF ENACYLOXIN IIa

TOSHIHIKO WATANABE, TAKEYOSHI SUGIYAMA, MASAHIRO TAKAHASHI, JUN SHIMA, KYOHEI YAMASHITA, KAZUO IZAKI, KAZUO FURIHATA, HARUO SETO

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JOURNAL FREE ACCESS

1992 Volume 45 Issue 4 Pages 470-475

DOI https://doi.org/10.7164/antibiotics.45.470

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Abstract

The chemical structure of a unique polyenic antibiotic enacyloxin IIa (former name: fr. 2) produced by Frateuria (formerly Gluconobacter) sp. W-315 has been determined by extensive spectroscopic studies, in particular by NMR spectral analysis. It has a novel non-lactonic structure involving 3, 4-dihydroxycyclohexanecarboxylic acid with a chlorine-containing polyenic and polyhydroxy acyl side chain attached as an ester to the 3-hydroxyl substituent of the acid.

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