NEW PENEM COMPOUNDS WITH 5'-SUBSTITUTED PYRROLIDINYLTHIO GROUP AS A C-2 SIDE CHAIN; COMPARISON OF THEIR BIOLOGICAL PROPERTIES WITH THOSE OF CARBAPENEM COMPOUNDS

Abstract

A series of new penem compounds with a C-2 side chain consisting of a pyrrolidin-3'-ylthio group substituted with various aminocarbonyl groups at the C-5' position have been prepared. Antibacterial activity, stability to renal dehydropeptidase-I and affinity to penicillin-binding proteins of these compounds were investigated and compared with the corresponding carbapenem compounds.