BIOCHEMICAL STUDIES ON 2-DEOXY-SCYLLO-INOSOSE, AN EARLY INTERMEDIATE IN THE BIOSYNTHESIS OF 2-DEOXYSTREPTAMINE

I. CHEMICAL SYNTHESIS OF 2-DEOXY-SCFLLO-INOSOSE AND [2, 2-²H₂]-2-DEOXY-SCYLLO-INOSOSE

Abstract

A practical preparative method for 2-deoxy-scyllo-inosose, the earliest key intermediate leading to 2-deoxystreptamine, was devised as a prerequisite to more detailed biochemical studies on the biosynthesis of 2-deoxystreptamine. [2, 2-²H₂]-2-Deoxy-scyllo-inosose was also synthesized through a modified Ferrier reaction.