抄録
A series of new 3-[(Z)-2-methoxycarbonylvinylthio]-7β-[(2-aminothiazol-4-yl)acetamido]cephalosporins (1) having various oxyimino groups (Z-form) at the α position of the C-7 side chain was synthesized and evaluated for antibacterial activity and oral absorption in rats. Of these, the cephalosporin (1a) with a hydroxyimino group in the C-7 side chain showed a potent antibacterial activity against Gram-negative bacteria and Gram-positive Staphylococcus aureus as well as good oral absorption in rats. The structure-activity relationships of 1 are also presented.
