The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
BENARTHIN: A NEW INHIBITOR OF PYROGLUTAMYL PEPTIDASE
I. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITIES
TAKAAKI AOYAGI, MASAHIRO HATSU, FUKIKO KOJIMA, CHIGUSA HAYASHI, MASA HAMADA, TOMIO TAKEUCHI
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1992 Volume 45 Issue 7 Pages 1079-1083

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Abstract

We found benarthin, a new inhibitor of pyroglutamyl peptidase, in the fermentation broth of Streptomyces xanthophaeus MJ244-SF1. It was purified by column chromatography and centrifugal partition chromatography (CPC) and then was isolated as a colorless powder. The binding of benarthin was competitive with substrate and its inhibition constant (Ki) was 1.2 × 10-6M.

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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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