REVEROMYCINS, NEW INHIBITORS OF EUKARYOTIC CELL GROWTH
III. STRUCTURES OF REVEROMYCINS A, B, C AND D
1992 年 45 巻 9 号 p. 1420-1427
詳細
1992 年 45 巻 9 号 p. 1420-1427
Reveromycins A, B, C and D are new group inhibitors of the mitogenic activity of epidermal growth factor (EGF), produced by Streptomyces sp. Reveromycins are novel polyketide type antibiotics which have two terminal carboxylic groups, a spiroketal, a succinate and a varied side chain in the molecule. Determination of their structures by chemical and spectroscopic methods, in particular NMR studies, is described.
