THIAZOHALOSTATTN, A NEW CYTOPROTECTIVE SUBSTANCE PRODUCED BY Actinomadura I. TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL ACTIVITIES

YUJI YAMAGISHI; MICHIKO MATSUOKA; ATSUO ODAGAWA; SHINICHIRO KATO; KAZUTOSHI SHINDO; JUNICHIRO MOCHIZUKI

doi:10.7164/antibiotics.46.1633

THIAZOHALOSTATTN, A NEW CYTOPROTECTIVE SUBSTANCE PRODUCED BY Actinomadura

I. TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL ACTIVITIES

YUJI YAMAGISHI, MICHIKO MATSUOKA, ATSUO ODAGAWA, SHINICHIRO KATO, KAZUTOSHI SHINDO, JUNICHIRO MOCHIZUKI

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JOURNAL FREE ACCESS

1993 Volume 46 Issue 11 Pages 1633-1637

DOI https://doi.org/10.7164/antibiotics.46.1633

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Abstract

Thiazohalostatin has been isolated from the culture broth of Actinomadura sp. by a screening program designed to find novel cytoprotective substances. It was purified by use of column chromatography on silica gel, reversed phase HPLC and then isolated as colorless powder. Thiazohalostatin prevented cell death caused by calcium overload and exhibited an inhibitory activity against lipid peroxidation.

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