A NEW ANTIBIOTIC, CYPEMYCIN TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL CHARACTERISTICS

KANKI KOMIYAMA; KAZUHIKO OTOGURO; TOSHIAKI SEGAWA; KAZURO SHIOMI; HONG YANG; YOKO TAKAHASHI; MASAHIKO HAYASHI; TOSHIO OXANI; SATOSHI OMURA

doi:10.7164/antibiotics.46.1666

A NEW ANTIBIOTIC, CYPEMYCIN

TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL CHARACTERISTICS

KANKI KOMIYAMA, KAZUHIKO OTOGURO, TOSHIAKI SEGAWA, KAZURO SHIOMI, HONG YANG, YOKO TAKAHASHI, MASAHIKO HAYASHI, TOSHIO OXANI, SATOSHI OMURA

Author information

KANKI KOMIYAMA
The Kitasato Institute, and School of Pharmaceutical Sciences of Kitasato University
KAZUHIKO OTOGURO
The Kitasato Institute, and School of Pharmaceutical Sciences of Kitasato University
TOSHIAKI SEGAWA
The Kitasato Institute, and School of Pharmaceutical Sciences of Kitasato University
KAZURO SHIOMI
The Kitasato Institute, and School of Pharmaceutical Sciences of Kitasato University
HONG YANG
The Kitasato Institute, and School of Pharmaceutical Sciences of Kitasato University
YOKO TAKAHASHI
The Kitasato Institute, and School of Pharmaceutical Sciences of Kitasato University
MASAHIKO HAYASHI
The Kitasato Institute, and School of Pharmaceutical Sciences of Kitasato University
TOSHIO OXANI
Taiho Pharmaceutical Co., Ltd.
SATOSHI OMURA
The Kitasato Institute, and School of Pharmaceutical Sciences of Kitasato University

JOURNAL FREE ACCESS

1993 Volume 46 Issue 11 Pages 1666-1671

DOI https://doi.org/10.7164/antibiotics.46.1666

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Abstract

A new peptide antibiotic, cypemycin, with a molecular weight of 2, 097 (M + H), was isolated from the culture broth of Streptomyces sp. OH-4156. The antibiotic possesses cytocidal activity against P388 leukemia cells in vitro at a concentration of 1.3μg/ml (IC₅₀ values), and the antibiotic showed antimicrobial activities against Micrococcus luteus (MIC, 0.2μg/ml).

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