THIOMARINOL, A NEW HYBRID ANTIMICROBIAL ANTIBIOTIC PRODUCED BY A MARINE BACTERIUM FERMENTATION, ISOLATION, STRUCTURE, AND ANTIMICROBIAL ACTIVITY

HIDEYUKI SHIOZAWA; TAKESHI KAGASAKI; TAKESHI KINOSHITA; HIDEYUKI HARUYAMA; HARUKI DOMON; YUKIO UTSUI; KENTARO KODAMA; SHUJI TAKAHASHI

doi:10.7164/antibiotics.46.1834

THIOMARINOL, A NEW HYBRID ANTIMICROBIAL ANTIBIOTIC PRODUCED BY A MARINE BACTERIUM

FERMENTATION, ISOLATION, STRUCTURE, AND ANTIMICROBIAL ACTIVITY

HIDEYUKI SHIOZAWA, TAKESHI KAGASAKI, TAKESHI KINOSHITA, HIDEYUKI HARUYAMA, HARUKI DOMON, YUKIO UTSUI, KENTARO KODAMA, SHUJI TAKAHASHI

著者情報

ジャーナルフリー

1993 年 46 巻 12 号 p. 1834-1842

DOI https://doi.org/10.7164/antibiotics.46.1834

詳細

抄録

Thiomarinol, an antimicrobial antibiotic, was isolated from the culture broth of a marine bacterium, Alteromonas rava sp. nov. SANK 73390. Its structure was deduced as a hybrid composed of a pseudomonic acid analogue and holothin by NMR spectral analysis and chemical degradation. Antimicrobial activity against Gram-positive and Gram-negative bacteria of thiomarinol was stronger than both of pseudomonic acids and pyrrothine antibiotics.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）